A 2021 study found that participants were 2.5 times more likely to have mental distress when getting less than 6 hours of sleep on average compared to those who slept longer.

Cannabinoid research provides a new avenue for sleep treatments.

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https://www.cdc.gov/media/releases/2016/p0215-enough-sleep.html
https://www.nhlbi.nih.gov/health-topics/education-and-awareness/sleep-health
https://pubmed.ncbi.nlm.nih.gov/33108269/#:~:text=The%20global%20pooled%20prevalence%20rate,interval%2C%2028.7%2D95.6%25).
Foster, R. R., et al. (2020). «Endocannabinoids and Sleep: A Review of Pre-Clinical Evidence.» Pharmaceuticals (Basel) 13(8): 174. doi: 10.3390/ph13080174. PubMed PMID: 32785196; PubMed Central PMCID: PMC7388834.

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THCa vs. THC

As marijuana use in the US continues to rise, medical and recreational marijuana markets are being adjusted to further protect public health. More test are being done, leading consumers into a retail environment where the potency of various plant compounds, known as cannabinoids, are represented in percentages. T-H-Ca and T-H-C are the two cannabinoids most directly relating to the ‘high’ users receive.

The macroeconomic inertia behind this emerging industry has forced state and federal government agencies and private research firms, among others, to invest firmly in research of the plant, resulting in solid evidence cannabinoids, the various plant compounds producing the varied biological effects cannabis is known for, can have very different effects on the mind and body of humans and animals. One analysis of the differences by Kate Welch, a doctoral recipient and pharmacist, suggest both THCa and THC interact with the immune and nervous system, as well as various parts of the brain, yet the mechanism or route THCa and THC use to produce the biological effects is incredibly different – sometimes.

So…. What does it means to convert THCa to THC?

Expressing the differences between the two plant compounds can be done by examining the two cannabinoids at the molecular level. THCa is the carboxylic acid form of THC. With regard to THCa, a carboxylic acid describes the molecular structure including a carbon and oxygen molecule. Under normal circumstances, this prevents the psychoactive THC from being readily available. THCa, much like both CBDa and CBD, produces no psychoactive ‘high’ or related euphoria. The process of removing the carbon and oxygen molecules is done simply by adding heat. this is why eating raw marijuana will not get you stoned, but smoking or otherwise heating it will.

It is also important to note laboratory labels on medical or recreational cannabis usually lists both THCa and THC concentrations. If the THCa is testing at 18% and the THC is testing at 1.5%, it may be easily assumed the product – once activated by heat – will be 19.5% THC. This is inaccurate. THCa percentages must be multiplied by the molecular mass of THC before being translated into final THC potential.

Interestingly, the analysis released by Kate Welch the pharmacist, suggests THCa can produce at least two clinically significant outcomes more effectively than THC can.

THe First being that — THCa and THC can both provide anti-nausea and anti-vomiting effects, yet research suggests THC is less potent than THCa. In rat studies, the effect of THCa on nausea and vomiting is described as ‘considerable’ and was shown to inhibit these effects by activating serotonin receptors.

#2… THCa is more effective than THC at managing inflammation, pain THCa and THC both have clinical potential as an anti-inflammatory and pain reliever, having even been shown to engage similar biological pathways to achieve this effect as ibuprofen or aspirin. Additionally, THCa may work better than THC as a neuroprotective In animal studies. research on the cannabinoids THCa and THC, has suggested the cannabinoid may have a neuroprotective effect.. What That means is cells, rather than degenerating, are encouraged to continue along healthfully. In so doing, this slows the rate an illness such as Parkinson’s disease can radicalize cells.

Individuals with neurodegenerative diseases such as Parkinson’s have been seeking beyond the realm of traditional western medicine and turning to medical marijuana for their condition, which currently has no cure.

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Lyrics:
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Eh, eheu, eheu
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Eh, eheu, eheu
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And the walls kept tumbling down in the city that we love
Grey clouds roll over the hills, bringing darkness from above

But if you close your eyes
Does it almost feel like nothing changed at all?
And if you close your eyes
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How am I gonna be an optimist about this?
How am I gonna be an optimist about this?

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And the walls kept tumbling down in the city that we love
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How am I going to be an optimist about this?
How am I going to be an optimist about this?
If you close your eyes
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Eh, eheu, eheu
Eh, eheu, eheu
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