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A Delta plane crashed at Toronto Pearson International Airport and injured eight people, officials said, even as the plane flipped on landing. A video from CTV showed the plane belly up on a snow-covered tarmac, as fire engines spray it

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John Krasinski highlights some good news around the world (including weather from Emma Stone) and has his friends from The Office join in to surprise a newly married couple. Special thanks to Emily Blunt for the intro and Zac Brown for the live performance!

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To pre-save Zac Brown Band’s new song «The Man Who Loves You The Most», click here: https://smarturl.it/TMWLYTM

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La noche del domingo anunció su veto a la SB-3 la cual habría prohibido los productos de tetrahidrocannabinol o THC, Delta-8 y Delta-9, dijo que, en su lugar de una prohibición total, desea que se promueva enfoque regulatorio más estructurado.
https://telemundoaustin.com/news/local/gobernador-de-texas-veta-proyecto-de-ley-que-prohibiria-productos-de-thc
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Telemundo Austin es una estación con sede en Texas y una afiliada de CBS Television propiedad y operada por Sinclair Broadcast Group. Sinclair Broadcast Group, Inc. es una de las compañías de transmisión de televisión más grandes y diversificadas del país en la actualidad.

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Welcome to Ambient TRIPPs! Immerse yourself in 8 hours of deep, calming lava sounds on a black screen, perfectly designed to help you achieve profound relaxation, uninterrupted sleep, and enhanced focus.

This unique ambient experience features a carefully embedded 130.8Hz Delta binaural beat frequency, known for its ability to promote deep sleep, meditation, and a state of focused concentration. Whether you’re looking to drift off to sleep, block out distractions while studying, or find a tranquil backdrop for your meditation practice, this video is your ideal companion.

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Get Sweaty with Leddy is a wellness channel dedicated to pain management. The creator, Josh Leddy, has lived with chronic pain since 1995 and is hellbent on preventing people from the cyclical trap of doctor visits, prescriptions, pain pills, and surgery through natural processes The goal is to provide numerous avenues to address all types of pain from: physical, mental, visible, invisible, internal, external, work-related, sport-related, acute, chronic, neuropathic, and more.

Primarily a podcast where guests sit in a sauna and talk about various experiences with pain, and how they’ve overcome such adversity, followed by a cold plunge in Lake Minnetonka. A true wellness component within a wellness program.

Additionally, Josh will provide short, and long, supporting content to highlight specific elements of pain management. You’ll learn firsthand how he manages to fight pain while engaging in an active lifestyle. Let the healing begin!

Follow & Contact us HERE
Instagram: https://www.instagram.com/leddyjosh/

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Unlocking the Secrets of THC and CBD | What are the HEALTH Benefits? | Get Sweaty with Leddy EP21

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​​Best CBD Gummies for Anxiety & Stress – 2025 Comparison​​

Menopause and the menstrual cycle can be physically and emotionally challenging for many women, bringing with them a wave of symptoms like hot flashes, cramps, mood swings, anxiety, fatigue, and insomnia. These menopause-related symptoms can feel overwhelming, but natural solutions like CBD oil for women are showing promising results in easing discomfort during both PMS and menopause.

In this video, we’ll explore how CBD (Cannabidiol)—a safe, non-psychoactive compound extracted from the hemp plant—can serve as a powerful natural remedy and mood stabilizer to help women navigate hormonal shifts, especially during menopause and perimenopause, with more comfort and control.

You’ll also learn how CBD supports women during menopause by working through the Endocannabinoid System (ECS) to restore hormonal balance, reduce inflammation, and support emotional and physical well-being. These effects are especially helpful during the menopausal transition, when estrogen levels drop, leading to intensified symptoms like hot flashes, irritability, and insomnia.

Whether you’re dealing with PMS or facing menopause symptoms like night sweats, low energy, and mood swings, this video will guide you through how CBD oil can help manage menopause naturally and effectively.

⚠ Note: Always consult with your healthcare provider before using any CBD products, especially if you are pregnant or breastfeeding.

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Dopo il Delta-8, c’è un altro cannabinoide del quale sia sta discutendo parecchio, si chiama esaidrocannabinolo (HHC) ed ecco quello che c’è da sapere

Articolo di riferimento:
– https://www.dolcevitaonline.it/hhc-nuovo-cannabinoide-centro-attenzione

Articoli di approfondimento:
– https://www.prnewswire.com/news-releases/boston-hemp-explains-hhc-and-its-effects-301438573.html
– https://www.dolcevitaonline.it/delta-8-thc-che-cose-e
– https://www.dolcevitaonline.it/fumare-cannabis-e-fame-chimica

—

Seguiteci..
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Understanding CBD and Xarelto Interactions

In recent years, cannabidiol (CBD) has gained immense popularity as a natural remedy for various health issues, including anxiety, chronic pain, and inflammation. Extracted from the cannabis plant, CBD is non-psychoactive and is often hailed for its potential therapeutic benefits. Meanwhile, Xarelto, a brand name for rivaroxaban, is an anticoagulant medication designed to prevent blood clots in conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE), and in patients undergoing certain surgeries. While both substances can be beneficial for patient health, understanding their interaction is crucial for ensuring patient safety.

The primary concern surrounding the combination of CBD and Xarelto lies in how CBD can affect the metabolic processes that govern the efficacy and safety of Xarelto. Xarelto is primarily eliminated from the body through the liver, specifically by the cytochrome P450 enzyme system, particularly CYP3A4. CBD can interact with this enzyme, potentially leading to increased or decreased levels of Xarelto in the bloodstream. This variability can impact the drug’s effectiveness or enhance the risk of bleeding—a severe side effect of anticoagulants—making it essential for patients to engage in open conversations with their healthcare providers regarding CBD use.

This article delves into the critical interactions between CBD and Xarelto, exploring three essential warnings that individuals should heed if they are considering the concurrent use of these substances. By examining the pharmacokinetics of both CBD and Xarelto, along with relevant studies and clinical observations, we can clarify how these substances interact within the body. Such understanding is vital for anyone navigating the complexities of using CBD alongside prescription medications, particularly anticoagulants like Xarelto.

Pharmacological Mechanism of CBD

The pharmacology of cannabidiol (CBD) is intricate and involves a variety of biological systems. CBD’s therapeutic effects are thought to arise primarily from its interaction with the endocannabinoid system (ECS), which plays a critical role in regulating physiological processes such as pain, mood, appetite, and immune function. The ECS comprises cannabinoid receptors (CB1 and CB2), endocannabinoids, and metabolic enzymes. By modulating this system, CBD exerts anti-inflammatory, analgesic, and anxiolytic effects, making it appealing to those looking for natural alternatives to conventional medications.

However, CBD’s interaction with other drugs cannot be understated. The liver metabolizes many substances through various cytochrome P450 enzymes, including CYP3A4 and CYP2C19. CBD has been shown to inhibit CYP3A4 activity, leading to a higher concentration of drugs that are processed through this pathway. In the context of anticoagulants like Xarelto, an increased concentration may lead to enhanced anticoagulation and a heightened risk of bleeding. Therefore, understanding this mechanism is key to evaluating the safety of using CBD while on such medications.

The way CBD interacts with drug metabolism is also influenced by individual factors such as genetics, current health conditions, and the overall presence of other medications. These interactions complicate the process of determining safe CBD dosages for individuals on anticoagulant therapy, particularly given the potential consequences of drug concentration changes. Consequently, patients who are considering CBD should approach the idea cautiously and inform their healthcare providers before initiating treatment.

Xarelto’s Anticoagulant Properties

Xarelto (rivaroxaban) belongs to the class of medications known as direct oral anticoagulants (DOACs), which work by directly inhibiting Factor Xa, a crucial component in the coagulation cascade responsible for blood clot formation. By preventing the activation of thrombin and ultimately the conversion of fibrinogen to fibrin, Xarelto effectively reduces the ability of blood to clot. This action is particularly beneficial for individuals at risk for thromboembolic events, such as those with atrial fibrillation or following surgery.

The medication is well-regarded for its predictable pharmacokinetics, allowing for fixed dosing without the need for routine monitoring, making it a convenient alternative to older anticoagulants like warfarin. However, the risk of bleeding—both minor and major—remains a significant consideration for providers and patients alike. As a result, managing the regimen diligently and understanding potential interactions becomes pivotal for ensuring patient safety and efficacy.

Clinically, healthcare professionals utilize various factors, such as renal function, body weight, and concurrent medications, to customize dosing for Xarelto. Providers are specifically attentive to white patients as they are often at a heightened risk of experiencing complications. Therefore, when combining Xarelto with substances like CBD, which has implications for drug metabolism, the spectrum of potential interactions intensifies, necessitating careful discussions between patients and their healthcare team regarding any supplementary therapies.

Potential Risks of Combining CBD and Xarelto

The potential risks associated with the concurrent use of CBD and Xarelto are primarily rooted in alterations to the pharmacokinetic profile of Xarelto due to CBD’s interaction with the CYP450 enzyme system. One significant risk involves the unexpected elevation of Xarelto levels in the bloodstream. Elevated levels can lead to an increased anticoagulant effect, raising the likelihood of bleeding complications, which may range from minor bruising to life-threatening hemorrhages.

On the other hand, some individuals might experience decreased levels of Xarelto if the metabolic pathway is induced instead, which may diminish the drug’s effectiveness. This poses its own set of risks, particularly for patients relying on Xarelto to manage serious conditions associated with thrombosis or embolism. The unpredictable nature of such interactions underscores the importance of monitoring when patients are advised to combine the two substances.

Furthermore, the lack of widespread clinical research into the chronic use of CBD alongside Xarelto amplifies concerns about safety. While there are anecdotal reports regarding the benefits of CBD for pain management or anxiety relief, the potential for unpredictable drug interactions warrants serious consideration. Patients should avoid self-medicating with CBD without the guidance of a qualified healthcare provider, as the consequences of higher or lower drug levels may have serious outcomes.

Consultation and Safety Guidelines

For individuals currently prescribed Xarelto, consulting with a healthcare professional prior to starting CBD is imperative. Healthcare providers can evaluate the unique health profile of each patient, including any other medications they might be taking and their overall health condition. Such consultations provide a tailored approach, allowing healthcare providers to gauge the risks of interaction and suggest safer alternatives or modifications if necessary.

Patients should also thoroughly discuss their CBD products, including dosage, frequency, and method of delivery, with their healthcare providers. Different forms of CBD—such as oils, capsules, or edibles—may have distinct effects on drug metabolism. The concentration of CBD in these products can vary widely, leading to discrepancies in interaction severity. Therefore, sharing this information ensures that providers can track the complete pharmaceutical landscape of their patients, promoting safety and efficacy.

Continuous monitoring of the patient’s blood thinning level is critical in cases where CBD is used alongside Xarelto. Providers might recommend periodic blood tests to determine the coagulation status, adjusting the dosage of Xarelto accordingly based on individual responses. This strategy helps mitigate the risks associated with potential drug interactions, providing a safety net for patients.

Common Inquiries Regarding CBD and Xarelto

Understanding the intersection between CBD and Xarelto leads to many frequently asked questions among patients considering their concurrent use. One common inquiry revolves around whether it is entirely safe to use CBD products while taking Xarelto. While the answer may not be straightforward, discussing this with a healthcare provider can clarify individual risks and benefits.

Another prevalent question often concerns the types of CBD that might be safer to use. Full-spectrum, broad-spectrum, and isolate products vary in their composition of cannabinoids and other active compounds, which can influence their interaction with prescription medications. As patients explore these options, consulting a knowledgeable professional is essential for determining the best course of action based on the individual’s medical history and needs.

Lastly, many patients express curiosity about the potential therapeutic effects of CBD in managing side effects associated with anticoagulant therapy. While some report experiencing benefits such as pain relief or anxiety reduction, scientific evidence remains varied. Therefore, while patients may find incidental benefits using CBD, these should never overshadow the need for adequate monitoring and professional guidance to ensure overall health and safety in conjunction with medications like Xarelto.

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We square measure awake to however distinctive healthful properties of CBD have helped it earn a reputationthat nearly describes magic. A large-scale study has unveiled the advantages of CBD in neutralizing the wrath of cancer cells, infectious microbes, and alternative health problems. however with all the thrill emergence around CBD, what most numbers of publication diaries and CBD oil reviews forgot to debate is its basic role contend

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There is a lot of debate going around as to what the difference is between CBD and THC and why, where cannabis is concerned, it is of any importance.

CBD is short for cannabidiol while THC is short for tetrahydrocannabinol, which may help you to understand why people prefer to use the abbreviations!

In addition, CBD and THC are just two of the over 130 cannabinoids found in the cannabis plant.
Cannabinoids, when they enter the bloodstream, attach themselves to cannabinoid receptors in the brain, which in itself has its own endocannabinoid system.

This is why the difference between THC and CBD becomes important.
Once attached to a cannabinoid receptor, brain neurons are admitted which affect the way we feel, and different neurons are emitted when THC attaches itself to a cannabinoid receptor than those emitted when CBD attaches itself.

That is why CBD has a more calming effect on your mind and body, while THC, which has psychoactive properties, makes you ‘high’, the euphoric effect many reactional smokes strive for.

Advances in science have now revealed that there are even more differences between CBD and THC.
CBD is now believed to act against anxiousness, is neuroprotective, is an anti-convulsant and can act as a painkiller and anti-inflammatory agent.

THC promotes euphoria, sleepiness and drowsiness, and is an appetite stimulant – known as “the munchies” – it’s also a painkiller and anti-emetic.

Of course this list goes on and on, and we’d love to know What are your thoughts are on the differences.

have you experienced anything other than what we have discussed?

Let us know in the comments below, and of course if you enjoyed this video make sure to subscribe to our channel, so you too can become a cannabis expert!

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With the legalization of cannabis gaining momentum in many states, the market for THC-infused products has exploded in recent years. One of the most popular options for users looking to enjoy the benefits of THC without the need to smoke is THC gummies. These delicious treats offer a convenient and discrete way to consume cannabis, making them a favorite among both seasoned users and newcomers alike.

Top Picks for the Best THC Gummies of 2022

When it comes to finding the best THC gummies on the market, there are a few key factors to consider. From potency and flavor to ingredient quality and price, there are plenty of variables that can impact your overall experience. To help you navigate this crowded market, we’ve compiled a list of the top THC gummies of 2022 based on user reviews, expert opinions, and our own testing.

1. Kanibi Organi Gummies

Kanibi Organi Gummies are a top choice for those looking for a high-quality, organic option. These gummies are made with all-natural ingredients and are free of artificial colors, flavors, and preservatives. Each gummy contains 10mg of THC, making it easy to customize your dose based on your individual needs. Users rave about the delicious flavors and potent effects of Kanibi Organi Gummies.

2. Cheef Botanicals Vegan THC Gummies

For those with dietary restrictions, Cheef Botanicals Vegan THC Gummies are an excellent choice. These gummies are gluten-free, vegan, and non-GMO, making them a great option for those with dietary sensitivities. Each gummy contains 25mg of THC, providing a potent dose that is sure to have you feeling relaxed and euphoric. Users love the natural ingredients and great taste of Cheef Botanicals Vegan THC Gummies.

3. Verma Farms Tropical Cherry THC Gummies

If you’re looking for a delicious and exotic option, look no further than Verma Farms Tropical Cherry THC Gummies. These gummies are made with real fruit juice and come in a variety of tropical flavors, including cherry, mango, and pineapple. Each gummy contains 20mg of THC, providing a well-balanced dose that is perfect for both beginners and experienced users. Users appreciate the mouth-watering flavors and smooth effects of Verma Farms Tropical Cherry THC Gummies.

4. CBDistillery Vegan THC Gummies

CBDistillery Vegan THC Gummies are a popular choice for those looking for a potent and affordable option. These gummies are made with broad-spectrum hemp extract and are vegan-friendly, gluten-free, and non-GMO. Each gummy contains 30mg of THC, making it a great option for those looking for a more intense experience. Users praise the potent effects and great value of CBDistillery Vegan THC Gummies.

5. Sunday Scaries Vegan Unicorn Jerky THC Gummies

For a fun and whimsical option, check out Sunday Scaries Vegan Unicorn Jerky THC Gummies. These gummies are made with all-natural ingredients and come in a variety of fruity flavors, including strawberry, blue raspberry, and grape. Each gummy contains 15mg of THC, providing a moderate dose that is perfect for unwinding after a long day. Users enjoy the playful packaging and relaxing effects of Sunday Scaries Vegan Unicorn Jerky THC Gummies.

Summary and FAQs

As you can see, the market for THC gummies is vast and varied, offering a wide range of options to suit every taste and preference. Whether you’re looking for a potent dose, a delicious flavor, or a vegan-friendly option, there is something out there for everyone. Before trying any new THC gummies, be sure to read reviews, check the ingredient list, and start with a small dose to gauge your tolerance.

Q: What is the best way to store THC gummies?

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A: To preserve the freshness and potency of your THC gummies, store them in a cool, dark place away from sunlight and heat sources. Be sure to keep them out of reach of children and pets.

Q: How long do THC gummies take to kick in?

A: The effects of THC gummies typically kick in within 30-60 minutes after consumption. However, this can vary depending on factors such as metabolism, tolerance, and whether you’ve eaten recently.

Q: Are THC gummies legal?

A: The legality of THC gummies varies by state and country. Be sure to check the laws in your area before purchasing or consuming THC gummies.

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Some of my crew felt relief in just days, and I can’t wait to tell you why these are different.

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Why These Gummies Changed Our Lives

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My Personal ‘Golden Calm’ Routine:

1️⃣ Take one gummy after dinner
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👉 Pro Tip: For tough days, take two gummies – but start with one to find your perfect dose!

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Questions? Drop them below! I check comments daily and love helping friends find wellness solutions that actually work.

Here’s to your health journey – can’t wait to hear your success stories! 🌟

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We do not condone or support illegal activities, including the use of any controlled substances. This video is for educational purposes only. Always comply with the laws and regulations in your region.

Marijuana, particularly due to its active compound THC, can have a variety of side effects, which vary depending on the person, dosage, and frequency of use. Here are some common short-term and long-term side effects:

Short-Term Side Effects:

1. Altered Senses: Marijuana can change how you perceive things, affecting your sense of time, colors, sounds, and even touch.

2. Impaired Memory and Thinking: Marijuana affects short-term memory and cognitive functions, making it harder to concentrate, learn new things, or recall information.

3. Increased Heart Rate: After using marijuana, your heart rate can increase, which might raise the risk of heart-related issues in those with pre-existing conditions.

4. Coordination Problems: THC impairs motor skills, which can make tasks like driving or handling machinery dangerous.

5. Dry Mouth and Eyes: A common side effect of marijuana is a feeling of dry mouth (often called «cottonmouth») and dry, red eyes.

6. Euphoria or Anxiety: Some users feel relaxed and happy, while others might experience anxiety, paranoia, or panic, especially in high doses or for inexperienced users.

7. Hunger: Often referred to as «the munchies,» marijuana can increase appetite.

8. Hallucinations (in high doses): Some users may experience hallucinations or delusions when consuming large amounts.

Long-Term Side Effects:

1. Addiction: Regular use of marijuana can lead to dependence. Some people develop a marijuana use disorder, where they struggle to stop using even when it negatively affects their life.

2. Respiratory Issues: Smoking marijuana can lead to chronic bronchitis, coughing, and other lung issues similar to tobacco use.

3. Cognitive Decline: Long-term use, especially when started in adolescence, can result in cognitive decline, reduced IQ, and memory problems.

4. Mental Health Issues: Prolonged marijuana use has been linked to increased risks of depression, anxiety, and psychosis, particularly in individuals with a predisposition to mental health disorders.

5. Impaired Brain Development (in teens): Studies suggest that marijuana use in adolescents may interfere with brain development, leading to long-lasting cognitive and behavioral effects.

6. Decreased Motivation: Chronic marijuana use can lead to a lack of motivation or interest in pursuing goals, known as amotivational syndrome.

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